Faulty genes linked to obesity in women, had no effect in men

New Delhi, August 04, 2023.

Faulty variants of three genes have been linked to obesity-related conditions, while having no effect on men, shedding light on new biological pathways underlying obesity, according to a new study.

“There are a million and one reasons why we should be thinking about sex, age, and other specific mechanisms rather than just lumping everyone together and assuming that disease mechanism works the same way for everyone,” said senior author John Perry, a geneticist and professor at the University of Cambridge, UK.

The research team sequenced the exome – protein-coding part of the genome – of more than 4,14,000 adults from the UK Biobank study and looked at variants, or mutations, within genes associated with body mass index (BMI) in men and women, respectively. They have published their findings in the journal Cell Genomics.